No. 15, September 2022. En of the book keep sharp, CNN health correspondent Sanjay Gupta proposes five pillars for maintaining mental sharpness: diet, exercise, rest, purpose in life, and social connection. When someone asks him which of these pillars predominates, his answer is surprising: it is neither diet nor crossword puzzles, but exercise, movement. Believe it or not, Gupta, a neurologist, presents evidence that exercise is "the only activity that triggers biological effects that can maintain a healthy brain."